BMN Colchicine, Captcha, beer, bonfires and Jesus

 

Brian’s Morning Newsletter for March 16th 2009
Slim's Big bonfire

 

Slim’s Big Bonfire Friday the 13th 2009


Good Morning
Nice weekend except for the severe gout attack I had on Saturday, probably due to the fun I had on Friday. Damnitall. Yeah, Slim called at 8:00 AM Friday to inform me that because of the nice little snowfall and subsequent ground covering, he was going to light up a pile of saw mill scrap later that morning.  Oh boy, the guys were going to have some fun. I rousted Kevin and loaded up my dog in the Trooper and we headed off to Slim’s old mill. By the time we arrived it was 11:30 AM, Slim, Richard, Zack, and Jose were standing by a nice pile of sticks which they had lit an hour earlier.

 

Zack Slim and Kevin admire the fire while a steady stream of traffic flies by at 75 miles per hour in the background on Interstate 25.

 

 

One possible cause for the trigger of my gout attack  was the beer we began drinking at noon, and kept on drinking until we loaded back into the Trooper and headed into town for Friday afternoon banking. Jose brought  wienies and buns, so  we did eat a good lunch cooked over a small piece of the fire carefully shoveled from the glowing coals of the bonfire.  Whether or not the beer did it or the guilt from drinking did it to me, I was done in by Saturday morning. Immobilized with a swollen ankle, I took two Colchicine before dawn on Saturday, and two more after Saturday morning Netflix movie madness, or at least I think I did.  By that time, the first two pills were barely killing the pain and swelling, but had me fading in and out of consciousness for the day.  Thank goodness I have Nell. She did everything except go to the bathroom for me. Thank you honey. I ‘m sure it gets tiresome fetching everything for a miserable man.

 


I don’t remember much about Saturday, but Sunday, I woke in considerably better shape.  I worked on my web site  for a while  and learned some interesting stuff about Captcha which I posted in detail below just in case you are interested. Just in case you are not I will quickly say that Captcha seen here:  


It turns out that I finally decided to try Captcha on my site www.outfitnm.com for registration well after it had been cracked, by the very hackers it is meant to keep out. Captcha  was created to keep bots (mechanized spammers)  from registering as users on discussion forums, and posting advertisements. 

"Captcha is a type of challenge-response test used in computing to ensure that the response is not generated by a computer. " In effect, Captcha is a computer asking a user if it is human. If only we could make a telephone answering machine determine if the caller is human.  Anyway, I tried a new Captcha package called botproof Captcha made for Word Press, but it wasn’t compatible with the version installed at www.outfitnm.com so I deactivated it and went back to Sabre and tweaked it for greater image distortion. This setting seems to be holding the bots at bay, at least only one made it through last night. They create user names like Wlkjsdfsai@gmail.com and I suppose since the hackers also cracked Gmail captcha at the same time they now can get an email account to use for registration confirmation.

Unfortunately I got to see the metamorphosis of the Captcha hack in action. It truly is amazing how the hackers cracked Captcha using OCR (Optical Character Recognition) software. OCR is the software that can read a Fax (facsimile) or scanned document and basically guess what letters or numbers the dots on the paper are. To apply OCR to Captcha is smart, super smart even.

Here I said I wasn’t going to go on about that hacker crap and I did anyway.  I guess you can tell that even though I say I’m no longer into computers, I still find some of this interesting.

Sunday morning Nell and I got dressed in our Sunday finest and accompanied Mom, Jack and Dad on a trip to Chacon, where Pop, I mean, the honorable Reverend Henry S. Rodgers was going to deliver his post retirement sermon at the mountaintop Presbyterian church.   The gist of the sermon was Bible verses and subjectivity. Dad puts on a very good sermon. The front cover of bulletin read" Take these things out of here, Stop making my father’s house a market place! John 2.16" We had no idea where he was going to to go with this and he soon brought it all together.  Reverend Rodgers was questioning the tone of  the story about Jesus flipping  over the tables of the Money Exchangers. Even though Dad condones Jesus’ alleged actions in Jerusalem all those years ago, he was more concerned that flipping tables over wasn’t in character for the Jesus we have come to know and love.

My father makes a fine point, in that all of us have a tendency to make a story mean what we want it to mean. Instead, Dad suggests we question the stories we are told. Of course Dad’s sermon was much more than than this, but that is what I gathered from what he preached. Questions, more than answers, how can we go wrong with that? Thanks dad, you always get us thinking.    

Sincerely,
Brian Rodgers

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Mar 16
2009

Agnes - March 16, 2009

 

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Mar 16
2009

Wizard of Id - March 16, 2009

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Colchicine

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Colchicine
Systematic (IUPAC) name
N-​[(7S)-​1,​2,​3,​10-​tetramethoxy-​9-​oxo-​5,​6,​7,​9-​tetrahydrobenzo​[a]​heptalen-​7-​yl]​acetamide
Identifiers
CAS number 64-86-8
ATC code M04AC01
PubChem 6167
ChemSpider 5933
Chemical data
Formula C22H25NO6 
Mol. mass 399.437
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 9.3 – 10.6 hours
Excretion Primarily feces, urine 10-20%
Therapeutic considerations
Pregnancy cat.

X

Legal status

RX/POM

Routes Oral tablets

Colchicine is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (Autumn crocus, Colchicum autumnale, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition. In neurons, axoplasmic transport is disrupted by colchicine.

Contents

[hide]

[edit] History

Colchicum extract was first described as a treatment for gout in De Materia Medica by Pedanius Dioscorides in the first century CE. Colchicine, an alkaloid, was first isolated in 1820 by the two French chemists P.S. Pelletier and J. Caventon.[1] The alkaloid was later identified as a tricyclic alkaloid, and its pain-relieving and anti-inflammatory effects for gout were linked to its ability to bind with tubulin.

[edit] Pharmacology

[edit] Biological function

Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules. Availability of tubulin is essential to mitosis, and therefore colchicine effectively functions as a "mitotic poison" or spindle poison.[2] Since one of the defining characteristics of cancer cells is a significantly increased rate of mitosis, this means that cancer cells are significantly more vulnerable to colchicine poisoning than are normal cells. However, the therapeutic value of colchicine against cancer is (as is typical with chemotherapy agents) limited by its toxicity against normal cells.

Apart from inhibiting mitosis, a process heavily dependent on cytoskeletal changes, colchicine also inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect. Colchicine also inhibits uric acid (urate) crystal deposition, which is enhanced by a low pH in the tissues, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. The inhibition of uric acid crystals is a vital aspect on the mechanism of gout treatment.

[edit] Colchicine as medicine

In the United States colchicine by itself is not FDA approved, however it is still prescribed for the treatment of gout and also for familial Mediterranean fever,[3] secondary amyloidosis(AA), and scleroderma. It is also used as an anti-inflammatory agent for long-term treatment of Behçet’s disease.

The Australian biotechnology company Giaconda has developed a combination therapy to treat constipation-predominant irritable bowel syndrome which combines colchicine with the anti-inflammatory drug olsalazine.

The British drug development company Angiogene is developing a prodrug of colchicine, ZD6126[4] (also known as ANG453) as a treatment for cancer.

Colchicine has a relatively low therapeutic index.

Colchicine is "used widely" off-label by naturopaths for a number of treatments, including the treatment of back pain.[5]

[edit] Side effects

Side effects include gastro-intestinal upset and neutropenia. High doses can also damage bone marrow and lead to anaemia. Note that all of these side effects can result from hyper-inhibition of mitosis.

[edit] Toxicity

Colchicine poisoning has been compared to arsenic poisoning: symptoms start 2 to 5 hours after the toxic dose has been ingested and include burning in the mouth and throat, fever, vomiting, diarrhea, abdominal pain and kidney failure. These symptoms may set in as many as 24 hours after the exposure. Onset of multiple-system organ failure may occur within 24 to 72 hours. This includes hypovolemic shock due to extreme vascular damage and fluid loss through the GI tract, which may result in death. Additionally, sufferers may experience kidney damage resulting in low urine output and bloody urine; low white blood cell counts (persisting for several days); anemia; muscular weakness; and respiratory failure. Recovery may begin within 6 to 8 days. There is no specific antidote for colchicine, although various treatments do exist.[6]

[edit] Botanical use

Since chromosome segregation is driven by microtubules, colchicine is also used for inducing polyploidy in plant cells during cellular division by inhibiting chromosome segregation during meiosis; half the resulting gametes therefore contain no chromosomes, while the other half contain double the usual number of chromosomes (i.e., diploid instead of haploid as gametes usually are), and lead to embryos with double the usual number of chromosomes (i.e. tetraploid instead of diploid). While this would be fatal in animal cells, in plant cells it is not only usually well tolerated, but in fact frequently results in plants which are larger, hardier, faster growing, and in general more desirable than the normally diploid parents; for this reason, this type of genetic manipulation is frequently used in breeding plants commercially. In addition, when such a tetraploid plant is crossed with a diploid plant, the triploid offspring will be sterile, which may be commercially useful in itself by requiring growers to buy seed from the supplier, but also can often be induced to create a "seedless" fruit if pollinated (usually the triploid will also not produce pollen, therefore a diploid parent is needed to provide the pollen). This is the method used to create seedless watermelons, for instance. On the other hand, colchicine’s ability to induce polyploidy can be exploited to render infertile hybrids fertile, as is done when breeding triticale from wheat and rye. Wheat is typically tetraploid and rye diploid, with the triploid hybrid infertile. Treatment with colchicine of triploid triticale gives fertile hexaploid triticale.

When used to induce polyploidy in plants, colchicine is usually applied to the plant as a cream. It has to be applied to a growth point of the plant, such as an apical tip, shoot or sucker. Seeds can be presoaked in a colchicine solution before planting. As colchicine is so dangerous, it is worth noting that doubling of chromosome numbers can occur spontaneously in nature, and not infrequently. The best place to look is in regenerating tissue. One way to induce it is to chop off the tops of plants and carefully examine the lateral shoots and suckers to see if any look different.[7] If there is no visual difference flow cytometry can be used for analysis.

 

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CAPTCHA

From Wikipedia, the free encyclopedia

  (Redirected from Captcha)
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Early CAPTCHAs such as these, generated by the EZ-Gimpy program, were used on Yahoo!. However, technology was developed to read this type of CAPTCHA[1]

 

A modern CAPTCHA, rather than attempting to create a distorted background and high levels of warping on the text, might focus on making segmentation difficult by adding an angled line

 

Another way to make segmentation difficult is to crowd symbols together. This, though, is often very difficult for humans to read

A CAPTCHA or Captcha (IPA: /ˈkæptʃə/) is a type of challenge-response test used in computing to ensure that the response is not generated by a computer. The process usually involves one computer (a server) asking a user to complete a simple test which the computer is able to generate and grade. Because other computers are unable to solve the CAPTCHA, any user entering a correct solution is presumed to be human. Thus, it is sometimes described as a reverse Turing test, because it is administered by a machine and targeted to a human, in contrast to the standard Turing test that is typically administered by a human and targeted to a machine. A common type of CAPTCHA requires that the user type letters or digits from a distorted image that appears on the screen.

The term "CAPTCHA" was coined in 2000 by Luis von Ahn, Manuel Blum, Nicholas J. Hopper (all of Carnegie Mellon University), and John Langford (then of IBM). It is a contrived acronym for "Completely Automated Public Turing test to tell Computers and Humans Apart." Carnegie Mellon University attempted to trademark the term,[2] but the trademark application was abandoned on 21 April 2008.[3] Currently, CAPTCHA creators recommend use of reCAPTCHA as the official implementation.[4]

Contents

[hide]

[edit] Characteristics

A CAPTCHA system is a means of automatically generating new challenges which:

  • Current software is unable to solve accurately.
  • Most humans can solve
    • The visually disabled who rely on screen reading technology cannot solve a visual CAPTCHA, thus limiting or preventing their access to some sites (see below for accessibility considerations)
  • Does not rely on the type of CAPTCHA being new to the attacker.

Although a checkbox "check here if you are not a bot" might serve to distinguish between humans and computers, it is not a CAPTCHA because it relies on the fact that an attacker has not spent effort to break that specific form.

Withholding of the algorithm can increase the integrity of a limited set of systems, as in the practice of security through obscurity. The most important factor in deciding whether an algorithm should be made open or restricted is the size of the system. Although an algorithm which survives scrutiny by security experts may be assumed to be more conceptually secure than an unevaluated algorithm, an unevaluated algorithm specific to a very limited set of systems is always of less interest to those engaging in automated abuse. Breaking a CAPTCHA generally requires some effort specific to that particular CAPTCHA implementation, and an abuser may decide that the benefit granted by automated bypass is negated by the effort required to engage in abuse of that system in the first place.

[edit] History

Moni Naor was the first person to theorize a list of ways to verify that a request comes from a human and not a bot.[5] Primitive CAPTCHAs seem to have been developed in 1997 by Andrei Broder, Martin Abadi, Krishna Bharat, and Mark Lillibridge to prevent bots from adding URLs to their search engine.[6] In order to make the images resistant to OCR (Optical Character Recognition), the team simulated situations that scanner manuals claimed resulted in bad OCR. In 2000, Luis von Ahn and Manuel Blum coined the term ‘CAPTCHA’, improved and publicized the notion, which included any program that can distinguish humans from computers. They invented multiple examples of CAPTCHAs, including the first CAPTCHAs to be widely used, which were those adopted by Yahoo!.

[edit] Applications

CAPTCHAs are used to prevent automated software from performing actions which degrade the quality of service of a given system, whether due to abuse or resource expenditure. CAPTCHAs can be deployed to protect systems vulnerable to e-mail spam, such as the webmail services of Gmail, Hotmail, and Yahoo! Mail. CAPTCHAs are also used on Wikipedia for anonymous or new users who attempt to add links.

CAPTCHAs have found active use in stopping automated posting to blogs, forums and wikis, whether as a result of commercial promotion, or harassment and vandalism. CAPTCHAs also serve an important function in rate limiting, as automated usage of a service might be desirable until such usage is done in excess, and to the detriment of human users. In such a case, a CAPTCHA can enforce automated usage policies as set by the administrator when certain usage metrics exceed a given threshold. The article rating systems used by many news web sites are another example of an online facility vulnerable to manipulation by automated software.[7]

[edit] Accessibility

Because CAPTCHAs rely on visual perception, users unable to view a CAPTCHA (for example, due to a disability or because it is difficult to read) will be unable to perform the task protected by a CAPTCHA. Therefore, sites implementing CAPTCHAs may provide an audio version of the CAPTCHA in addition to the visual method. The official CAPTCHA site recommends providing an audio CAPTCHA for accessibility reasons.

[edit] Attempts at more accessible CAPTCHAs

Even an audio and visual CAPTCHA will require manual intervention for some users, such as those who have visual disabilities and also are deaf. There have been various attempts at creating CAPTCHAs that are more accessible. Attempts include the use of JavaScript, mathematical questions ("what is 1+1" or even more complex problems like derivatives or polynomial factorization — also known as a MAPTCHA, or Mathematical CAPTCHA), or "common sense" questions ("what color is the sky on a clear day").

[edit] Circumvention

There are a few approaches to defeating CAPTCHAs:

  • exploiting bugs in the implementation that allow the attacker to completely bypass the CAPTCHA,
  • improving character recognition software, or
  • using cheap human labor to process the tests.

[edit] Insecure implementation

Like any security system, design flaws in a system implementation can prevent the theoretical security from being realized. Many CAPTCHA implementations, especially those which have not been designed and reviewed by experts in the fields of security, are prone to common attacks.

Some CAPTCHA protection systems can be bypassed without using OCR simply by re-using the session ID of a known CAPTCHA image. A correctly designed CAPTCHA does not allow multiple solution attempts at one CAPTCHA. This prevents the reuse of a correct CAPTCHA solution or making a second guess after an incorrect OCR attempt.[8] Other CAPTCHA implementations use a hash (such as an MD5 hash) of the solution as a key passed to the client to validate the CAPTCHA. Often the CAPTCHA is of small enough size that this hash could be cracked.[9] Further, the hash could assist an OCR based attempt. A more secure scheme would use an HMAC. Finally, some implementations use only a small fixed pool of CAPTCHA images. Eventually, when enough CAPTCHA image solutions have been collected by an attacker over a period of time, the CAPTCHA can be broken by simply looking up solutions in a table, based on a hash of the challenge image.

[edit] Computer character recognition

A number of research projects have attempted (often with success) to beat visual CAPTCHAs by creating programs that contain the following functionality:

  1. Pre-processing: Removal of background clutter and noise.
  2. Segmentation: Splitting the image into regions which each contain a single character.
  3. Classification: Identifying the character in each region.

Steps 1 and 3 are easy tasks for computers.[10] The only step where humans still outperform computers is segmentation. If the background clutter consists of shapes similar to letter shapes, and the letters are connected by this clutter, the segmentation becomes nearly impossible with current software. Hence, an effective CAPTCHA should focus on the segmentation.

Several research projects have broken real world CAPTCHAs, including one of Yahoo’s early CAPTCHAs called "EZ-Gimpy"[1] and the CAPTCHA used by popular sites such as Paypal,[11] LiveJournal, phpBB, and other open source solutions.[12][13][14] In January 2008 Network Security Research released their program for automated Yahoo! CAPTCHA recognition.[15] Windows Live Hotmail and Gmail, the other two major free email providers, were cracked shortly after.[16][17]

In February 2008 it was reported that spammers had achieved a success rate of 30% to 35%, using a bot, in responding to CAPTCHAs for Microsoft’s Live Mail service[18] and a success rate of 20% against Google’s Gmail CAPTCHA.[19] A Newcastle University research team has defeated the segmentation part of Microsoft’s CAPTCHA with a 90% success rate, and claim that this could lead to a complete crack with a greater than 60% rate.[20]

[edit] Human solvers

CAPTCHA is vulnerable to a relay attack that uses humans to solve the puzzles. One approach involves relaying the puzzles to a group of human operators who can solve CAPTCHAs. In this scheme, a computer fills out a form and when it reaches a CAPTCHA, it gives the CAPTCHA to the human operator to solve.

Another variation of this technique involves copying the CAPTCHA images and using them as CAPTCHAs for a high-traffic site owned by the attacker. With enough traffic, the attacker can get a solution to the CAPTCHA puzzle in time to relay it back to the target site.[21] In October 2007, a piece of malware appeared in the wild which enticed users to solve CAPTCHAs in order to see progressively further into a series of striptease images.[22][23]

These methods have been used by spammers to set up thousands of accounts on free email services such as Gmail and Yahoo!. [24] Since Gmail and Yahoo! are unlikely to be blacklisted by anti-spam systems, spam sent through these compromised accounts is less likely to be blocked.

[edit] Legal concerns

The circumvention of CAPTCHAs may violate the anti-circumvention clause of the Digital Millennium Copyright Act (DMCA) in the United States. In 2007, Ticketmaster sued software maker RMG Technologies[25] for its product which circumvented the ticket seller’s CAPTCHAs on the basis that it violates the anti-circumvention clause of the DMCA. In October 2007, an injunction was issued stating that Ticketmaster would likely succeed in making its case.[26] In June 2008, Ticketmaster filed for Default Judgment against RMG. The Court granted Ticketmaster the Default and entered an $18.2M judgment in favor of Ticketmaster.

CAPTCHA without audio may also violate the Americans With Disabilities Act, according to the American Council for the Blind.[27]

[edit] Image-recognition CAPTCHAs

Some researchers promote image recognition CAPTCHAs as a possible alternative for text-based CAPTCHAs. To date only rapidshare made use of an image based CAPTCHA. Many amateur users of the phpBB forum software (which has suffered greatly from spam) have implemented an open source image recognition CAPTCHA system in the form of an addon called KittenAuth[28] which in its default form presents a question requiring the user to select a stated type of animal from an array of thumbnail images of assorted animals. The images (and the challenge questions) can be customized, for example to present questions and images which would be easily answered by the forum’s target userbase. Furthermore, for a time, RapidShare free users had to get past a CAPTCHA where you had to only enter letters attached to a cat, while others were attached to dogs.[29] This was later removed because users had trouble entering the correct letters.

Image recognition CAPTCHAs face many potential problems which have not been fully studied. It is difficult for a small site to acquire a large dictionary of images which an attacker does not have access to and without a means of automatically acquiring new labelled images, an image based challenge does not meet the definition of a CAPTCHA. KittenAuth, by default, only had 42 images in its database.[28] Microsoft’s "Asirra," which it is providing as a free web service, attempts to address this by means of Microsoft Research’s partnership with Petfinder.com, which has provided it with more than three million images of cats and dogs, classified by people at thousands of US animal shelters.[30] Unfortunately for Microsoft, researchers claim to have written a program than can break the Microsoft Asirra CAPTCHA.[31]

Human solvers are a potential weakness for strategies such as Asirra. If the database of cat and dog photos can be downloaded, then paying workers $0.01 to classify each photo as either a dog or a cat means that almost the entire database of photos can be deciphered for $30,000. Photos that are subsequently added to the Asirra database are then a relatively small data set that can be classified as they first appear. Causing minor changes to images each time they appear will not prevent a computer from recognizing a repeated image as there are robust image comparator functions (e.g., image hashes, color histograms) that are insensitive to many simple image distortions. Warping an image sufficiently to fool a computer will likely also be troublesome to a human.[32]

Another potential weakness is that only a yes/no answer for each picture is required by most designs. Even with sixteen images, a bot has a 1 in 65536 (216) chance of getting the CAPTCHA right purely by chance. Furthermore, such chance identifications can be used to accumulate knowledge about the correct identification of the images, allowing the bot to progressively improve the accuracy of its guesses over time. In order for the CAPTCHA to be resistant to such chance-guessing botnet attacks, the user would need to be forced to solve an annoyingly large number of images.

[edit] Collateral benefits

Some of the original inventors of the CAPTCHA system have implemented a means by which some of the effort and time spent by people who are responding to challenges can be harnessed as a distributed work system. This system, called reCAPTCHA, works by including "solved" and "unrecognized" elements (images which were not successfully recognized via OCR) in each challenge. The respondent thus answers both elements and roughly half of his or her effort validates the challenge while the other half is captured as work.[33]

 

4 comments to BMN Colchicine, Captcha, beer, bonfires and Jesus

  • Thanks Mary Beth, I hope this morning’s headline is equally intriguing “BMN tolerance – Jerry Springer, Harvey Milk”
    Something happened to the upload an avatar button in the users section, I’ve been fiddling with the settings, but it is still gone. I hope perseverance helps
    Brian

  •  mbkcrs

    Oh absolutely. It sounds like a great lesson too, particularly from a journalistic standpoint. Look at your sources, look at what you know about your subject and look at both sides of the story before you decide who’s right and who’s wrong.

    Interesting that your dad looked past the big story to question the unusual point of Jesus’ behavior.

    Never underestimate the power of a good headline to catch reader attention.

  • Well when you got down to the meat of the BMN what did you think about it? Dad’s sermon was great I hope I did it justice
    Brian

  •  mbkcrs

    I feel quite cozy looking at those pictures on this chilly morning. Wish I had seen that fire.

    And many thanks for the elk photos too. Wonderful. Funny they never show up during the Las Tusas Memorial Day get-together.

    Also, I want to give you high marks for an intriguing headline this morning. Colchicine, Captcha, beer, bonfires and Jesus… I couldn’t wait to see what that was all about.

    Warmly yours,

    MB